Instruments

DOLPHIN® ROTA ROD – DIGITAL 5 COMPARTMENT

 

CODE : 1268

ROTA ROD-DIGITAL

 

Rota Rod is the instrument meant for studying the effect of diazepam on the muscle – grip strength of mice.

 

A versatile instrument built with LSI Chips is equipped with three compartments and three independent 4 digits Digital milliseconds timer for measuring the fall-off time of the mice.

 

It is also equipped with a motor coupled with rotating rod whose speed can be varied with the help of the front panel knob marked with an arrow or speed less than 10 RPM.

Speed is marked from 5 RPM to 35 RPM.

 

One of the important pharmacological actions of antianxiety agents of benzodiazepine class of drugs is muscle relaxing property. The skeletal muscle relaxation together with taming or calming effect these agents reduce anxiety and tension. The loss of muscle-grip is an indication of muscle relaxation. This can be easily checked in animals using Rota Rod.

 

The difference in the fall off time from the rotating rod between the control and diazepam treated animal is taken as index of muscle relaxation. The rate of rotation of the rod should be adjusted such that a normal mouse can stay on the rod for an appropriate period of time.

 

OPERATION

 

  • Before switching ON the instrument, ensure that the platforms in which the mice has to fall are laying in the backward direction. This platform is basically a SEA-SAW adjustment such that when animal or mice fell down from the rotating rod, this platform also pressed in the forward direction thereby stops the timer and the time is recorded in the timer until it is resetted.
  • After this switch ON the instrument. There are chances that random reading may appear in the digital timer displays.
  • Now RESET the timers with the help of the PUSH SWITCHES provided below the TIME DISPLAY.
  • After all this adjustments, press the PUSH SWITCH marked START.

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